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Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy, also known as Krabbe's Disease, is a genetically inherited condition belonging to a category known as "storage diseases." A storage disease occurs when a particular enzyme, which is necessary for a normal process within the body, is deficient, and as a result, the compound which the enzyme normally acts upon builds up. This build-up leads to the expression of the disease and its symptoms, typically not at birth, but generally at a consistent age for each specific storage disease.

In the case of Globoid Cell Leukodystrophy, the deficient enzyme is galactocerebroside beta-galactosidase. This enzyme normally is involved in the breakdown of fats in the brain and spinal cord. When it is deficient, the compound galactocerebroside begins to build up. Galactocerebroside is a component of myelin, which is the fatty substance that surrounds and insulates nerve cells, keeping the electrical impulses properly isolated within the cells. When Galactocerebroside builds up, the production of myelin is affected, and as a result, there is a progressive loss of the myelin sheath on nerve cells in the brain and spinal cord.

Age of Onset
Puppies affected with Globoid Cell Leukodystrophy are normal at birth, but they may begin showing symptoms as early as four weeks or as late as six months. Basset Hounds are the exception, since they may not show symptoms for several years.

Symptoms of Globoid Cell Leukodystrophy
Symptoms are typically progressive (gradually worsening) and include stiffness when walking, weakness, lack of balance and coordination, tremors, loss of control (especially of hindquarters), and typically will eventually progress to paralysis and possible blindness. As would be expected, there are also generally behavioral changes that occur in conjunction with the physiological symptoms.
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My frenid Joan in My frenid Joan in Toronto was featured on Dogs With Jobs in Canada about 10 years ago. She had´╗┐ a standard poodle named Morgan as her narcolepsy service dog, and to our knowledge he was the first in the world. Joan now has Shaba as her service dog. Because the collapses in narcolepsy are actually paralysis (cataplexy) rather than sleep, Shaba's job is to drag her to a safe place when she's going to collapse, and stand over her and protect her while she's down. Was this

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Featured Puppy Announcements

Featured Breed -

Chihuahua

The Chihuahua At a Glance
Recognized By AKC, CanKC, UKC, CKC, KCUK, FCI, AFDSB
Country of Origin Mexico
Life Expectancy 14 years
Height Range 6 - 9 in
Weight Range 1.5 to 6 lbs
Colors Virtually any color and
markings acceptable
including tri-color,
blue, and brindle
Trainability High
With Children Usually good
With Animals Can be territorial
Climate Warm weather
Indoor/Outdoor Indoor
Exercise Reqd Moderate
Grooming Reqd Low; long coat moderate
Chihuahua Information
Although it's the world's smallest breed, the Chihuahua is hardly aware of that. They may be small and often fragile, but they are quite spunky and can be quite bold. However, they generally suffer in cold climates and need to be indoors. They can be quite aloof with strangers, and their bark can make them a good warning dog. They may have either a short or long coat.




The Myth of the Teacup

The Chihuahua Is A Chihuahua



Sponsored by The Chihuahua Club of America



The official A.K.C. Breed Standard describes the Chihuahua as a small dog that comes in two varieties or coat types. The difference in coat type (the Long Coat or the Smooth Coat) is the only official description used to identify a difference within this breed. Our Standard does not categorize the Chihuahua by size.



For the purpose of showing and record keeping, the American Kennel Club includes the Chihuahua (along with 16 other breeds) in the Toy Group. Therefore, irrespective of their weight or physical stature, ALL Chihuahuas registered with A.K.C. are considered to be a toy breed of dog.



As with all living things, there will be a size variance between individual dogs within this breed. Within the human family, brothers and sisters will differ in height and in weight, as well as other physical attributes. They are described as humans, male or female, and there is seldom if ever a need to break the description down further. The same holds true in regard to the Chihuahua; they are Chihuahuas-Long Coat/Smooth Coat, Male/Female.



Unfortunately, the additional adjectives used to describe the size difference and physical appearances are many; and have been misused for so long they now seem legitimate. Teacup, Pocket Size, Tiny Toy, Miniature or Standard - are just a few of the many tags and labels that have been attached to this breed over the years. The Chihuahua Club of America is concerned that these terms may be used to entice perspective buyers into thinking that puppies described in this way are of greater monetary value. They are not; and the use of these terms is incorrect and misleading. Occasionally, within a litter, there may be a puppy that is unusually small. That puppy is a small Chihuahua and any other breakdown in description is not correct. To attach any of these additional labels to a particular pup is to misrepresent that animal as something that is rare or exceptional and causes a great deal of confusion among those fanciers who are looking for a Chihuahua.



The Chihuahua Club of America does not endorse or condone the use of any of these terms and would caution the perspective puppy buyer not to be misled by them. We recognize that many Chihuahua fanciers do want the very small puppy. While they are adorable and can be perfectly healthy, the buyer should be cautioned as to the extra care that may be required with regard to their general health and well-being.

Click to find:   Chihuahua Puppies For Sale   |   Chihuahua Breeders   |   Chihuahua Information

Dog Question of the Week

Some answers to last week's question:
What's the coolest dog name you ever heard?
This Week's Question:
Do you think dogs can read our emotions?
We met a couple at the pet supply store who's dog was named ""Ed."" You know a dog named Ed is gonna be cool!
Ed from Ft Worth, TX, USA
I think the coolest dog name EVER is ""Strudel."" Probably has to be a German dog, though, like a German Shepherd.
Callie from Ann Arbor, MI, USA
I have heard some good ones over the years but I rather like my own. Three of them are Veruca, Sweeney (Todd) and Ellen Degeneres.
Jessica from Hawley, PA, USA
Riverstead's Mad Dog Skull Cap ""Deogie pronounced D.O.G.
Anonymous from Halifax, Nova Scotia, CAN
biscuit
allan from bangalore, karnataka, India
Dog Question of the Week
Do you think dogs can read our emotions?
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