The Online Home For Dog Breeders

Featuring Dog Breeders, Puppies For Sale, and Dog Breeds

Bookmark and Share


Support Dog
Health Testing
For Healthier Puppies
QualityDogs.com is your home for puppies, dog breeders, and dog health information. If you are a dog lover who is interested in learning about dog breeds, researching dog breeders, or even finding a puppy to add to your home, you are in the right place. To find current puppies for sale by site members, or to search our entire dog breeders list by breed, click on the menu bar to the left. While you are here, don't forget to check our out informative Dog Articles section, and post your own pictures and comments on our Breed Profile pages!
Are you a responsible dog breeder? Click here to find out how to join QualityDogs.com and appear on the site!
Latest Blog Entries
Good Morning America! :-)
Posted 11/16/2014
It's a crisp, cold day up here in northern Minnesota! We have snow on the ground, the sun is shining, and it's a great day to bundle up, take the pups out for a walk, and then come back in for hot chocolate! Loving Labradors! Denise and Rob The Captain's Labradors...
More

Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy, also known as Krabbe's Disease, is a genetically inherited condition belonging to a category known as "storage diseases." A storage disease occurs when a particular enzyme, which is necessary for a normal process within the body, is deficient, and as a result, the compound which the enzyme normally acts upon builds up. This build-up leads to the expression of the disease and its symptoms, typically not at birth, but generally at a consistent age for each specific storage disease.

In the case of Globoid Cell Leukodystrophy, the deficient enzyme is galactocerebroside beta-galactosidase. This enzyme normally is involved in the breakdown of fats in the brain and spinal cord. When it is deficient, the compound galactocerebroside begins to build up. Galactocerebroside is a component of myelin, which is the fatty substance that surrounds and insulates nerve cells, keeping the electrical impulses properly isolated within the cells. When Galactocerebroside builds up, the production of myelin is affected, and as a result, there is a progressive loss of the myelin sheath on nerve cells in the brain and spinal cord.

Age of Onset
Puppies affected with Globoid Cell Leukodystrophy are normal at birth, but they may begin showing symptoms as early as four weeks or as late as six months. Basset Hounds are the exception, since they may not show symptoms for several years.

Symptoms of Globoid Cell Leukodystrophy
Symptoms are typically progressive (gradually worsening) and include stiffness when walking, weakness, lack of balance and coordination, tremors, loss of control (especially of hindquarters), and typically will eventually progress to paralysis and possible blindness. As would be expected, there are also generally behavioral changes that occur in conjunction with the physiological symptoms.
-Read the whole article
Read on! Check out:   Dog Health   |   Dog Nutrition   |   Training   |   Grooming   |   more articles
Recent Visitor Comments
Glen of Imaal Terrier
Recently we rescued of Glen of Imaal from our local SPCA. She is 4 yrs old and is a very focused little girl. A mind of her own, not real affectionate, but very loyal at the same time. She has trained me well.

Akita
I've owned 2 male Akitas. They've both been very healthy, low maintenance, friendly to humans, have lived with other pets but are NOT good with other males. Don't require a great deal of exercise.. A walk twice a day is plenty. Mine chew ice cubes after a walk. Neither of them showed any real interest in chewing anything else, but this has proven to keep their teeth and gums healthy and it's kind of funny, too. Can't sing their praises enough. Wonderful family membe

Coton de Tulear
My frenid Joan in My frenid Joan in Toronto was featured on Dogs With Jobs in Canada about 10 years ago. She had´╗┐ a standard poodle named Morgan as her narcolepsy service dog, and to our knowledge he was the first in the world. Joan now has Shaba as her service dog. Because the collapses in narcolepsy are actually paralysis (cataplexy) rather than sleep, Shaba's job is to drag her to a safe place when she's going to collapse, and stand over her and protect her while she's down. Was this

Post your comments in our Breed Profiles
Featured Puppy Announcements

Featured Breed -

Chinese Shar-Pei

The Chinese Shar-Pei At a Glance
Recognized By AKC
Country of Origin China
Life Expectancy 9 - 11 yrs
Height Range 18 - 20 in
Weight Range 35 - 60 lbs
Colors Any solid
Trainability Easy, but can be stubborn
With Children Excellent
With Animals Depends; should be raised with them
Climate Any
Indoor/Outdoor Indoor
Exercise Reqd Not much
Grooming Reqd Little; care for skin folds
Chinese Shar-Pei Information
The Chinese Shar-Pei has been in the United States since 1972. For over 20 years, it was commonly over-bred with little concern for its genetic weaknesses and indiscriminantly sold to whomever had enough money. The results were disastrous. Today's reputable breeders are waging a relentless battle to reduce those inherited problems, like skin conditions, kidney failure, hip and knee defects, entropion, cancer, and blindness. Even though questionable temperaments seem to be an issue of the past, the drawbacks of owning a Shar-Pei still exist unless buyers do their homework and research not only the breed but the person they buy it from.



Since being recognized by the American Kennel Club in 1992, the Chinese Shar-Pei stands proud in show rings from coast to coast, but in some cases, that too has had a negative effect on this breed's welfare. When breeders only concentrate on what will win in the ring, health issues can take a back seat to breed type. Therefore, when selecting a Shar-Pei, it is important to remember that titles alone do not guarantee good health. Only responsible, researched breeding against health problems will contribute to the improvement of the breed's health and help to insure healthy individual dogs. But regardless of all this, the breed has endured in the last 30+ years. The Shar-Pei remains unique, fun, and endearing from pupyhood to senior citizen status. Quality breeders are bringing health back to this fascinating breed, and choosing a breeder wisely will help contribute to the overall well-being of the Shar-Pei.



Contributed by Ellana Clarke, www.chi-kuan-sharpei.com
Click to find:   Chinese Shar-Pei Puppies For Sale   |   Chinese Shar-Pei Breeders   |   Chinese Shar-Pei Information

Dog Question of the Week

Some answers to last week's question:
What breed do you think is best for people in the city?
This Week's Question:
Do you take your dog to a groomer?
Pug
joshua from miraj, maharashtra, India
rat terrier
sarah from star city, arkanasas, USA
A Yorkie is the ideal breed for the city. They need very little exercise- and are beautiful, intelligent, healthy and portable. Since they are small, its easy to keep and train them, with our busy modern lifestyle.
Lisa from Moultrie, GA, USA
tibetan terrier
Anonymous from USA
The bolonka of course! The Russian Tsvetnaya Bolonka was bred for life in a the city.
Thereasa from Phoenix, Az, USA
Dachshunds are curious, lively, charming, and brave. They are comical and love to play and they have a great sense of humor. They are very loyal and become very attached to their family, and they believe sleeping under the bed covers is in the Dachshund Bill of Rights. Dachshunds are often ke
Katherine from Dilliner, Pennsylvania, USA
Dog Question of the Week
Do you take your dog to a groomer?
Your first name
Your city
State/province
Country
 
By submitting, you grant QualityDogs.com the right to publish your submission (including your name/location if supplied) on this or affiliated websites, and to edit your submission for content, spelling, and/or grammar.
Google+