The Online Home For Dog Breeders

Featuring Dog Breeders, Puppies For Sale, and Dog Breeds

Bookmark and Share


Support Dog
Health Testing
For Healthier Puppies
QualityDogs.com is your home for puppies, dog breeders, and dog health information. If you are a dog lover who is interested in learning about dog breeds, researching dog breeders, or even finding a puppy to add to your home, you are in the right place. To find current puppies for sale by site members, or to search our entire dog breeders list by breed, click on the menu bar to the left. While you are here, don't forget to check our out informative Dog Articles section, and post your own pictures and comments on our Breed Profile pages!
Are you a responsible dog breeder? Click here to find out how to join QualityDogs.com and appear on the site!
Latest Blog Entries
Mini Schnauzers
Posted 7/29/2014
Eyes and ears are now open. We just turned 2 weeks and have complete our early neuro stimulation exercises. Next will be working on our walking. ...
More

Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency, or PK Deficiency, is the lack of a critical red blood cell enzyme (pyruvate kinase), which regulates the final step in the conversion of glucose to energy. As a result, red blood cells are not able to metabolize the energy required for the cells to function normally, which leads to a change in the cell membranes, a buildup of sodium ions inside the cell, a resulting swelling of the cell (as water molecules follow the buildup of sodium), and an eventual lysing (bursting) of the cell. Furthermore, there is a shortened life span of red blood cells as the abnormal cells are destroyed by the spleen and liver. To make matters worse, PK deficiency, through the changes described above, can shift the normal process by which hemoglobin stores and releases oxygen to body tissues. The end result of these changes produces "hemolytic anemia," which is a reduction in red blood cells and tissue oxygenation due to the rupture of abnormal red blood cells.

PK Deficiency Inheritance
Pyruvate Kinase Deficiency is an autosomal recessive trait, which means that, for a dog to have PK Deficiency, both parents must be either affected dogs themselves or carriers. Affected dogs will have two copies of the bad gene, while carriers will only have one copy and will not clinically show symptoms, although studies have shown that carriers do have a reduction in normal red blood cell enzyme activity.
-Read the whole article
Read on! Check out:   Dog Health   |   Dog Nutrition   |   Training   |   Grooming   |   more articles
Recent Visitor Comments
Glen of Imaal Terrier
Recently we rescued of Glen of Imaal from our local SPCA. She is 4 yrs old and is a very focused little girl. A mind of her own, not real affectionate, but very loyal at the same time. She has trained me well.

Akita
I've owned 2 male Akitas. They've both been very healthy, low maintenance, friendly to humans, have lived with other pets but are NOT good with other males. Don't require a great deal of exercise.. A walk twice a day is plenty. Mine chew ice cubes after a walk. Neither of them showed any real interest in chewing anything else, but this has proven to keep their teeth and gums healthy and it's kind of funny, too. Can't sing their praises enough. Wonderful family membe

Coton de Tulear
My frenid Joan in My frenid Joan in Toronto was featured on Dogs With Jobs in Canada about 10 years ago. She had´╗┐ a standard poodle named Morgan as her narcolepsy service dog, and to our knowledge he was the first in the world. Joan now has Shaba as her service dog. Because the collapses in narcolepsy are actually paralysis (cataplexy) rather than sleep, Shaba's job is to drag her to a safe place when she's going to collapse, and stand over her and protect her while she's down. Was this

Post your comments in our Breed Profiles
Featured Puppy Announcements

Featured Breed -

English Setter

The English Setter At a Glance
Recognized By AKC
Country of Origin England
Life Expectancy 10 - 15 yrs
Height Range 22 - 27 in
Weight Range 40 - 80 lbs
Colors White base coat with even flecking all over preferred. Flecks may be blue, orange, lemon, or liver. Tri colors are blue beltons with tan points. Field variety is more prone to patching.
Trainability Very trainable as long as a soft hand is used. Perceived as stubborn by those using a heavy-handed training method.
With Children Excellent. Very tolerant. Very high bite inhibition
With Animals Excellent with other animals except, of course, birds and rodents
Climate Comparable to humans
Indoor/Outdoor Indoor as they bond very tightly to their family
Exercise Reqd Fenced yard. Active as puppies but bench variety is calm in the house as adults. Field bred variety much more active
Grooming Reqd Field bred dogs need minimal grooming. Bench variety need routine grooming appointments
English Setter Information
The English setter is believed to have originated in England about 400 years ago. The field variety was primarily developed in America by Mr. Llwyellin. The bench variety was developed in this country by Mr. Laverack. The field variety is smaller both in height and weight than the bench variety. Both will usually hunt. The field variety, however, has a much higher energy level and is suitable for hunters on horse back as they range fairly far. The bench is more of a gentleman's hunting companion as he will usually not range far and is more suitable for hunters on foot. English setters are easily house trained. Like most puppies, they tend to chew when young. Like most sporting dogs, they should be taught to come relably when called before any attempts to let them off of a leash. This is a very soft, sensitive breed and does best with similar training methods. The English setter is, in general, a robust dog not commonly afflicted with ailments. The only problems relatively common to the breed are deafness, hip dysplasia and elbow dysplasia. Judious breeding by conscientious breeders has decreased the incidence of these problems in many lines of English setters. Prospective buyers should ask if parents have had their hearing BAER (Brainstem Auditory Evoked Response) tested and their hips and elbows evaluated by the OFA (Orthopedic Foundation for Animals). The English setter has maintained a very faithful following in many countries because of the breed's lovely disposition. The English setter is a wonderful family dog.

Information courtesy of Kaliber English Setters
Click to find:   English Setter Puppies For Sale   |   English Setter Breeders   |   English Setter Information

Dog Question of the Week

Some answers to last week's question:
What's the coolest dog name you ever heard?
This Week's Question:
Do you think dogs can read our emotions?
We met a couple at the pet supply store who's dog was named ""Ed."" You know a dog named Ed is gonna be cool!
Ed from Ft Worth, TX, USA
I think the coolest dog name EVER is ""Strudel."" Probably has to be a German dog, though, like a German Shepherd.
Callie from Ann Arbor, MI, USA
I have heard some good ones over the years but I rather like my own. Three of them are Veruca, Sweeney (Todd) and Ellen Degeneres.
Jessica from Hawley, PA, USA
Riverstead's Mad Dog Skull Cap ""Deogie pronounced D.O.G.
Anonymous from Halifax, Nova Scotia, CAN
biscuit
allan from bangalore, karnataka, India
Dog Question of the Week
Do you think dogs can read our emotions?
Your first name
Your city
State/province
Country
 
By submitting, you grant QualityDogs.com the right to publish your submission (including your name/location if supplied) on this or affiliated websites, and to edit your submission for content, spelling, and/or grammar.
Google+