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ears are crpped ready now
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Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy, also known as Krabbe's Disease, is a genetically inherited condition belonging to a category known as "storage diseases." A storage disease occurs when a particular enzyme, which is necessary for a normal process within the body, is deficient, and as a result, the compound which the enzyme normally acts upon builds up. This build-up leads to the expression of the disease and its symptoms, typically not at birth, but generally at a consistent age for each specific storage disease.

In the case of Globoid Cell Leukodystrophy, the deficient enzyme is galactocerebroside beta-galactosidase. This enzyme normally is involved in the breakdown of fats in the brain and spinal cord. When it is deficient, the compound galactocerebroside begins to build up. Galactocerebroside is a component of myelin, which is the fatty substance that surrounds and insulates nerve cells, keeping the electrical impulses properly isolated within the cells. When Galactocerebroside builds up, the production of myelin is affected, and as a result, there is a progressive loss of the myelin sheath on nerve cells in the brain and spinal cord.

Age of Onset
Puppies affected with Globoid Cell Leukodystrophy are normal at birth, but they may begin showing symptoms as early as four weeks or as late as six months. Basset Hounds are the exception, since they may not show symptoms for several years.

Symptoms of Globoid Cell Leukodystrophy
Symptoms are typically progressive (gradually worsening) and include stiffness when walking, weakness, lack of balance and coordination, tremors, loss of control (especially of hindquarters), and typically will eventually progress to paralysis and possible blindness. As would be expected, there are also generally behavioral changes that occur in conjunction with the physiological symptoms.
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Featured Puppy Announcements

Featured Breed -

Brussels Griffon

The Brussels Griffon At a Glance
Recognized By AKC
Country of Origin Belgium
Life Expectancy 12 - 15 yrs
Height Range 7 - 8 in
Weight Range 8 - 10 lbs
Colors Red, beige, black & tan, or black. No white hairs or markings
Trainability Can be good with a skilled and patient trainer; they tend to be stubborn
With Children Good with older children; can be nervous around overly active younger children
With Animals Very good; does well with other dogs and cats
Climate Intolerant of cold weather
Indoor/Outdoor Indoor with some outdoor time preferred; can do well in apartment/condo
Exercise Reqd Moderate to high; walks and play time are sufficient
Grooming Reqd Proper coat requires regular brushing and hand stripping by a knowledgeable groomer.
Brussels Griffon Information
The Brussels Griffon is a breed of toy dog named for the griffin, a mythological animal, which it is said to resemble. The Brussels griffon seems to have descended from a dog used by 17th-century Belgian peasants to rid their stables of rats. The ancestry of the modern breed includes the Affenpinscher, the Smooth-Coated Pug, and the Ruby Spaniel.

Conformation

Brussels Griffons have distinctive short, upturned faces, large, round heads, short noses, and unusually large and prominent black eyes. The male Griffon from 7 to 12 pounds. The female is slightly larger.

Disposition

The Brussels Griffon is intelligent, alert, sensitive, and full of self-importance with an almost human expression.

They are inside pets, good with other pets and children of all ages.

There are two types of coats, rough and smooth. They come in colors of Beige, Black, Black and Beige and Red.

Courtesy of Kelly Crawford, KMC-Kennels.
Click to find:   Brussels Griffon Puppies For Sale   |   Brussels Griffon Breeders   |   Brussels Griffon Information

Dog Question of the Week

Some answers to last week's question:
What special way do you spoil/pamper your dog?
This Week's Question:
Do you have clothes for your dog? Does he/she like them?
i give extra treats and treat him like he's the king but most of the time i give him more treats.
kate from leehigh, florida, USA
They sleep with me and I cook for them.
Bette from Aston, Pennsylvania, USA
By giving them treats even if they don't do any of the tricks you tell them to do whatsoever.
Indiya from Atlanta, Georgia, USA
Dog Question of the Week
Do you have clothes for your dog? Does he/she like them?
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