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shania puppies
Posted 5/9/2015
She has three puppies. Sheena a female and two males called spot and AJ all are black and white.They are all woolly Siberian huskies and they have had all their shots including their rabies shots and have been micro chipped. They have champion bloodline on their father side. http://www.qualitydogs.com/memberpics/142268/th_142268_0017.JPGhttp://www.qualitydogs.com/memberpics/142268/th_142268_http://www.qualitydogs.com/memberpics/142268/th_142268_0018.JPG0019.JPG...
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Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency, or PK Deficiency, is the lack of a critical red blood cell enzyme (pyruvate kinase), which regulates the final step in the conversion of glucose to energy. As a result, red blood cells are not able to metabolize the energy required for the cells to function normally, which leads to a change in the cell membranes, a buildup of sodium ions inside the cell, a resulting swelling of the cell (as water molecules follow the buildup of sodium), and an eventual lysing (bursting) of the cell. Furthermore, there is a shortened life span of red blood cells as the abnormal cells are destroyed by the spleen and liver. To make matters worse, PK deficiency, through the changes described above, can shift the normal process by which hemoglobin stores and releases oxygen to body tissues. The end result of these changes produces "hemolytic anemia," which is a reduction in red blood cells and tissue oxygenation due to the rupture of abnormal red blood cells.

PK Deficiency Inheritance
Pyruvate Kinase Deficiency is an autosomal recessive trait, which means that, for a dog to have PK Deficiency, both parents must be either affected dogs themselves or carriers. Affected dogs will have two copies of the bad gene, while carriers will only have one copy and will not clinically show symptoms, although studies have shown that carriers do have a reduction in normal red blood cell enzyme activity.
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Featured Puppy Announcements

Featured Breed -

Chinese Shar-Pei

The Chinese Shar-Pei At a Glance
Recognized By AKC
Country of Origin China
Life Expectancy 9 - 11 yrs
Height Range 18 - 20 in
Weight Range 35 - 60 lbs
Colors Any solid
Trainability Easy, but can be stubborn
With Children Excellent
With Animals Depends; should be raised with them
Climate Any
Indoor/Outdoor Indoor
Exercise Reqd Not much
Grooming Reqd Little; care for skin folds
Chinese Shar-Pei Information
The Chinese Shar-Pei has been in the United States since 1972. For over 20 years, it was commonly over-bred with little concern for its genetic weaknesses and indiscriminantly sold to whomever had enough money. The results were disastrous. Today's reputable breeders are waging a relentless battle to reduce those inherited problems, like skin conditions, kidney failure, hip and knee defects, entropion, cancer, and blindness. Even though questionable temperaments seem to be an issue of the past, the drawbacks of owning a Shar-Pei still exist unless buyers do their homework and research not only the breed but the person they buy it from.



Since being recognized by the American Kennel Club in 1992, the Chinese Shar-Pei stands proud in show rings from coast to coast, but in some cases, that too has had a negative effect on this breed's welfare. When breeders only concentrate on what will win in the ring, health issues can take a back seat to breed type. Therefore, when selecting a Shar-Pei, it is important to remember that titles alone do not guarantee good health. Only responsible, researched breeding against health problems will contribute to the improvement of the breed's health and help to insure healthy individual dogs. But regardless of all this, the breed has endured in the last 30+ years. The Shar-Pei remains unique, fun, and endearing from pupyhood to senior citizen status. Quality breeders are bringing health back to this fascinating breed, and choosing a breeder wisely will help contribute to the overall well-being of the Shar-Pei.



Contributed by Ellana Clarke, www.chi-kuan-sharpei.com
Click to find:   Chinese Shar-Pei Puppies For Sale   |   Chinese Shar-Pei Breeders   |   Chinese Shar-Pei Information

Dog Question of the Week

Some answers to last week's question:
Who was smarter: Benji or Lassie? Why?
This Week's Question:
What breed do you think is best for people in the city?
Lassie of course! Their is not a better dog then a Collie,loyal,protective,but not aggressive.No bad vices.The Only dog for a family with children,a best friend forever.And a perfect show dog for juniors,smart,eager to please.We love our Collies!!
Mickey from Star, NC, USA
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